Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Misoprostol therapeutics revisited.

N M Davies¹, J Longstreth, F Jamali

¹Faculty of Pharmacy, University of Sydney, New South Wales, Australia.

Pharmacotherapy

|February 24, 2001

Summary

Misoprostol, a prostaglandin E1 analog, offers broad therapeutic benefits beyond its gastrointestinal and uterotonic effects. This versatile medication demonstrates potential in managing various inflammatory, immunologic, and organ-specific conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

DHEA and response to antidepressant treatment: A Mendelian Randomization analysis.

Journal of psychiatric research·2024

Same author

Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, Update 2021.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2022

Same author

Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, Update 2020.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2021

Same author

Environmental effects of stratospheric ozone depletion, UV radiation and interactions with climate change: UNEP Environmental Effects Assessment Panel, update 2019.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2020

Same author

Accurate measurement of androgen after androgen esters: problems created by ex vivo esterase effects and LC-MS/MS interference.

Andrology·2018

Same author

Environmental effects of ozone depletion, UV radiation and interactions with climate change: UNEP Environmental Effects Assessment Panel, update 2017.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2018

Area of Science:

Pharmacology
Immunology
Gastroenterology

Background:

Misoprostol is a prostaglandin E1 analog rapidly converted to its active form, misoprostolic acid.
Misoprostolic acid has a short half-life and is excreted as inactive metabolites, with no significant drug interactions reported.

Purpose of the Study:

To explore the diverse therapeutic applications of misoprostol.
To highlight its immunomodulatory and organ-protective effects.

Main Methods:

Review of existing literature on misoprostol's pharmacological actions and clinical uses.
Analysis of misoprostol's effects on various biological cascades and disease models.

Main Results:

Misoprostol regulates immunologic cascades, inhibiting platelet-activating factor and leukocyte adherence.
Demonstrated efficacy in gastrointestinal protection, organ injury (liver, kidney, gut), inflammatory conditions, and post-transplant care.
Shown to improve nutrient absorption, reduce intraocular pressure, and synergize with other medications.

Conclusions:

Misoprostol possesses a wide range of therapeutic applications due to its anti-inflammatory and cytoprotective properties.
Its immunomodulatory actions contribute to its utility in diverse medical conditions, including organ transplantation and autoimmune diseases.

Related Experiment Videos