Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent progress in enantiomer separation by capillary electrochromatography.

D Wistuba1, V Schurig

  • 1Institute of Organic Chemistry, University of Tübingen, Germany. dorothee.wistuba@uni-tuebingen.de

Electrophoresis
|February 24, 2001
PubMed
Summary

This study reviews electrochromatographic enantiomer separation methods, including open-tubular, packed capillary, and monolithic capillary electrochromatography (CEC). It highlights new trends for efficient chiral separations using advanced stationary and mobile phases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-specific activity of (R)-(-)- and (S)- (+)-1,7-dioxaspiro[5.5]undecane, the major pheromone ofDacus oleae.

Journal of chemical ecology·2013
Same author

Male pheromone of swift moth,Hepialus hecta L. (Lepidoptera: Hepialidae).

Journal of chemical ecology·2013
Same author

Use of derivatized cyclodextrins as chiral selectors for the separation of enantiomers by gas chromatography.

Annales pharmaceutiques francaises·2010
Same author

A mixed stationary phase containing two versatile cyclodextrin-based selectors for the simultaneous gas chromatographic enantioseparation of racemic alkanes and racemic alpha-amino acid derivatives.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2008
Same author

The control of the nitrogen inversion in alkyl-substituted diaziridines.

Chemistry (Weinheim an der Bergstrasse, Germany)·2004
Same author

Accumulation of S(+) enantiomer in human beings after general anaesthesia with isoflurane racemate.

European journal of anaesthesiology·2002

Area of Science:

  • Analytical Chemistry
  • Separation Science

Background:

  • Enantiomer separation is crucial in pharmaceuticals and chemical synthesis.
  • Electrochromatography (CEC) offers a powerful platform for chiral separations.
  • Existing CEC modes include open-tubular, packed capillary, and monolithic capillary formats.

Purpose of the Study:

  • To provide a comprehensive overview of enantiomer separation techniques in electrochromatography.
  • To discuss emerging trends and novel approaches in CEC for chiral resolution.
  • To explore advancements in stationary and mobile phases for improved enantioseparation.

Main Methods:

  • Review of open-tubular capillary electrochromatography (o-CEC) with various chiral selector immobilization techniques.
  • Analysis of packed capillary electrochromatography (p-CEC) using chiral modified silica or achiral packing with mobile phase selectors.

Related Experiment Videos

  • Examination of monolithic (rod)-capillary electrochromatography (rod-CEC) utilizing integrated porous chiral stationary phases (CSPs).

    • Main Results:

    • Detailed comparison of the three primary CEC modes for enantiomer separation.
    • Discussion of innovative CEC strategies, including nonaqueous mobile phases and CSPs with permanent charges.
    • Exploration of novel packing materials like nonporous silica and sub-2µm particles for enhanced separation efficiency.

    Conclusions:

    • Capillary electrochromatography provides versatile strategies for enantiomer separation.
    • New trends in CEC, particularly in stationary and mobile phase design, are advancing chiral resolution.
    • Further research into novel materials and techniques promises more efficient and selective enantioseparations.