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Related Experiment Videos

Cryofibrination: did it really happen?

H Luckraz1, D Boolauky, A Mohangee

  • 1Cardiac Trust Fund, Pamplemousses. hluckraz@hotmail.com

Perfusion
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

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Cryofibrin precipitation, a cold-reactive protein deposition, can obstruct membrane oxygenators during cardiopulmonary bypass. This study details cases of this phenomenon using a specific oxygenator model.

Area of Science:

  • Cardiovascular Surgery
  • Biomedical Engineering
  • Hematology

Background:

  • Cryofibrin precipitation is a recently described phenomenon.
  • It may occur during cardiopulmonary bypass using membrane oxygenators.
  • Cold-reactive cryofibrin deposition can lead to circuit occlusion.

Purpose of the Study:

  • To describe the cryofibrination phenomenon.
  • To report clinical experiences with cryofibrin precipitation.
  • To investigate its occurrence with the Avecor-Affinity Medtronic membrane oxygenator.

Main Methods:

  • Case series description.
  • Analysis of clinical data related to membrane oxygenator use.
  • Observation of cryofibrin deposition and its effects.

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Main Results:

  • Cryofibrin deposition caused progressive occlusion in the oxygenator's heat-exchanger.
  • This occlusion resulted in a significant pressure-drop phenomenon.
  • The phenomenon was observed in patients using the Avecor-Affinity Medtronic membrane oxygenator.

Conclusions:

  • Cryofibrin precipitation is a potential complication in cardiopulmonary bypass.
  • It can impair membrane oxygenator function.
  • Further investigation into prevention and management is warranted.