Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human MUC1 mucin: a multifaceted glycoprotein.

S von Mensdorff-Pouilly1, F G Snijdewint, A A Verstraeten

  • 1Department of Obstetrics and Gynecology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands.

The International Journal of Biological Markers
|February 24, 2001
PubMed
Summary

MUC1 mucin, overexpressed in cancer, has a dual role in tumor progression and immune response. Early MUC1 antibody responses correlate with better survival, but MUC1 vaccines show limited efficacy in trials.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing cisplatin-based combination chemotherapy with EMA/CO chemotherapy for the treatment of high risk gestational trophoblastic neoplasia.

European journal of cancer (Oxford, England : 1990)·2012
Same author

Less mammographic density after nasal versus oral administration of postmenopausal hormone therapy.

Climacteric : the journal of the International Menopause Society·2011
Same author

Comparison of Hybrid capture 2 testing at different thresholds with cytology as primary cervical screening test.

British journal of cancer·2010
Same author

Therapeutic options for postmenopausal female sexual dysfunction.

Climacteric : the journal of the International Menopause Society·2009
Same author

The distribution of vasopressin and oxytocin in the rat brain.

Neuroscience letters·2009
Same author

Oncogenic pathways in hereditary and sporadic breast cancer.

Maturitas·2009

Area of Science:

  • Oncology
  • Immunology
  • Glycobiology

Background:

  • Human MUC1 mucin is a cell surface glycoprotein normally found on glandular cells.
  • MUC1 is overexpressed and aberrantly glycosylated in various carcinoma cells.
  • MUC1 plays a complex role in cancer, influencing cell adhesion, immune evasion, and immune responses.

Purpose of the Study:

  • To explore the dual role of MUC1 in cancer progression and immune response.
  • To investigate the potential of MUC1 as a tumor-associated antigen.
  • To review the clinical trial data of MUC1 peptide vaccines.

Main Methods:

  • Review of MUC1's role in cancer cell biology and immunology.
  • Analysis of MUC1 glycosylation changes in malignancy.
  • Examination of clinical trial data for MUC1 peptide vaccines.

Related Experiment Videos

Main Results:

  • Overexpressed MUC1 can promote metastasis by reducing cell adhesion and evading immune surveillance.
  • Altered MUC1 in cancer acts as a self-antigen, inducing humoral and cellular immune responses.
  • Natural antibodies to MUC1 in early-stage breast cancer patients are associated with improved survival.
  • Phase I clinical trials of MUC1 peptide vaccines primarily induced humoral responses, with limited evidence of clinical effectiveness.

Conclusions:

  • MUC1 is a significant tumor-associated antigen with a complex role in cancer immunity.
  • While natural MUC1 immunity may be beneficial, MUC1-targeted vaccines have shown limited success to date.
  • Further research is needed to develop effective MUC1-based cancer immunotherapies.