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Molecularly imprinted microparticles for capillary electrochromatographic enantiomer separation of propranolol
L Schweitz1, P Spégel, S Nilsson
1Technical Analytical Chemistry, Center for Chemistry and Chemical Engineering, Lund University, P O Box 124, SE-221 00 Lund, Sweden.
The Analyst
|February 24, 2001
Abstract:
Molecularly imprinted microparticles imprinted against (S)-propranolol were synthesised and studied for use in capillary electrochromatographic separation of propranolol enantiomers. The imprinted microparticles were in the size range of 0.2-0.5 micron as determined by scanning electron microscopy. The microparticles were suspended, in high concentration, in the electrolyte and used to perform enantiomer separation by a partial filling technique.