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Related Experiment Videos

Hypercholesterolemia in Shetland sheepdogs.

K Sato1, H Agoh, T Kaneshige

  • 1Department of Veterinary Internal Medicine, Faculty of Agriculture, Tottori University, Koyama, Japan.

The Journal of Veterinary Medical Science
|February 24, 2001
PubMed
Summary

Shetland sheepdogs have a higher incidence of hypercholesterolemia due to primary disorders in lipoprotein metabolism. This breed exhibits elevated cholesterol levels, particularly with abnormal alpha2-migrating lipoproteins.

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Area of Science:

  • Veterinary Medicine
  • Canine Health
  • Lipid Metabolism

Background:

  • Hypercholesterolemia is a concern in canine health.
  • Investigating breed-specific predispositions is crucial for understanding cholesterol disorders.
  • Shetland sheepdogs were evaluated for potential susceptibility to high cholesterol.

Purpose of the Study:

  • To determine if Shetland sheepdogs are more prone to hypercholesterolemia.
  • To identify the characteristics of lipoprotein abnormalities in affected dogs.
  • To explore potential primary disorders in lipid metabolism within the breed.

Main Methods:

  • Evaluated plasma lipoprotein cholesterol in 64 clinically healthy Shetland sheepdogs.
  • Compared cholesterol levels with control dogs.

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  • Performed cholesterol fractionation using agarose gel electrophoresis and ultracentrifugation.

    • Main Results:

    • Shetland sheepdogs showed a significantly higher incidence and mean plasma cholesterol level.
    • No underlying causative disorders were identified through biochemical examinations or thyroid hormone levels.
    • Accumulation of alpha2-migrating lipoproteins was common in dogs with cholesterol > 250 mg/dl.
    • Increased prebeta-beta-lipoproteins were observed in dogs with cholesterol > 500 mg/dl.

    Conclusions:

    • Hypercholesterolemia in Shetland sheepdogs appears to be a primary disorder.
    • The breed may have a higher prevalence of primary lipoprotein metabolism disorders.
    • Lipoprotein abnormalities, specifically alpha2-migrating lipoproteins, are characteristic of hypercholesterolemia in this breed.