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[Disseminated MALT lymphoma associated with macroglobulinemia]
S Iwase1, S Takahara, T Sekikawa
1Division of Hematology and Oncology, Jikei University Aoto Hospital.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|February 24, 2001
Summary
This case study describes a rare instance of disseminated MALT lymphoma with Waldenström macroglobulinemia in an elderly male. The lymphoma spread to the stomach, lungs, and bone marrow, ultimately leading to fatal respiratory distress.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- MALT lymphoma, a type of non-Hodgkin lymphoma, typically arises in extranodal sites.
- Waldenström macroglobulinemia is characterized by the overproduction of IgM monoclonal proteins.
Observation:
- An 80-year-old male presented with persistent fever, lung infiltration, and pleural effusion.
- Gastric examination revealed ulceration and MALT lymphoma infiltration.
- Immunophenotyping and histopathology confirmed lymphoma involving the stomach, lungs, and bone marrow.
Findings:
- The patient was diagnosed with disseminated MALT lymphoma and Waldenström macroglobulinemia (IgM kappa).
- Despite treatment with prednisolone, the lymphoma disseminated widely.
- A normal karyotype was observed in the lymphoid cells.
Implications:
- This case highlights the aggressive potential of disseminated MALT lymphoma.
- It underscores the importance of thorough investigation in patients with unexplained symptoms and lymphoma diagnosis.
- Further research into optimal treatment strategies for disseminated MALT lymphoma with macroglobulinemia is warranted.