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The angiotensin infusion test as a method of evaluating left ventricular function.

J A Ronan, R B Steelman, J P Schrank

    American Heart Journal
    |May 11, 1975
    PubMed
    Summary

    The angiotensin infusion method for measuring left ventricular function is unreliable. This study found variable responses in patients with and without heart disease, making it difficult to differentiate between groups.

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    Area of Science:

    • Cardiology
    • Physiology

    Background:

    • Assessing left ventricular function is crucial in cardiology.
    • The angiotensin infusion method has been explored as a diagnostic tool.

    Purpose of the Study:

    • To evaluate the reliability of the angiotensin infusion method for measuring left ventricular function.
    • To compare ventricular responses to angiotensin infusion in healthy individuals versus patients with coronary artery disease.

    Main Methods:

    • Left ventricular function was assessed using angiotensin infusion in 15 patients.
    • Patients were divided into two groups: those without heart disease (n=7) and those with coronary artery disease (n=8).
    • Cardiac index and heart rate changes were monitored during infusion, and ventricular function curves were analyzed.

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    Main Results:

    • Angiotensin infusion caused decreased cardiac index in both healthy subjects and those with coronary artery disease.
    • Ventricular function curves showed variable responses, with many exhibiting flat or descending slopes.
    • The method failed to reliably differentiate between patients with and without heart disease due to similar curve patterns.

    Conclusions:

    • The angiotensin infusion method yields highly variable results in left ventricular function assessment.
    • Factors like baroreceptor reflex, increased coronary resistance, and afterload likely contribute to the observed variability.
    • The angiotensin infusion method is not a reliable tool for evaluating ventricular function.