Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Permanent pacing in disorders of sinus node function.

V Krishnaswami, A R Geraci

    American Heart Journal
    |May 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A live-cell super-resolution technique demonstrated by imaging germinosomes in wild-type bacterial spores.

    Scientific reports·2020
    Same author

    Improving outpatient diabetes management through a collaboration of six competing, capitated Medicare managed care plans.

    American journal of medical quality : the official journal of the American College of Medical Quality·2000
    Same author

    Outpatient management of diabetes mellitus in five Arizona Medicare managed care plans.

    American journal of medical quality : the official journal of the American College of Medical Quality·1996
    Same author

    Effect of heart rate alterations produced by atrial pacing on the pattern of diastolic filling in normal subjects.

    The American journal of cardiology·1988
    Same author

    Simplified count-based estimates of left ventricular volume.

    Clinical nuclear medicine·1986
    Same author

    Left ventricular diastolic filling in patients with coronary artery disease and normal left ventricular function.

    American heart journal·1985
    Same journal

    Stratified Medicine with Eplerenone for Myocardial Infarction or Injury and No obstructive Coronary Arteries: A Registry-Based Basket Trial.

    American heart journal·2026
    Same journal

    Revised Lipid-Lowering Therapy Guidelines in a Nationally Representative Sample.

    American heart journal·2026
    Same journal

    Cardiometabolic Health of Low- and Higher-Income Adults in the United States, 2009-2023.

    American heart journal·2026
    Same journal

    Moving Beyond Technical Capability to Regulatory Integration for Digital Health Technology Devices-Brief Communication from the Cardiovascular Sciences Research Consortium.

    American heart journal·2026
    Same journal

    THE SOCIETY OF CRITICAL CARE CARDIOLOGY - RATIONALE, BLUEPRINT, AND LESSONS LEARNED IN THE CREATION OF A NEW MULTIDISCIPLINARY PROFESSIONAL ORGANIZATION.

    American heart journal·2026
    Same journal

    DOAC Score Among Patients Receiving Vitamin K Antagonists.

    American heart journal·2026
    See all related articles

    Permanent pacemakers effectively manage bradycardia in sinus node dysfunction. However, atrial fibrillation development can resolve dysfunction, but embolic risks and tachycardia remain significant concerns for patients.

    Area of Science:

    • Cardiology
    • Electrophysiology
    • Medical Devices

    Background:

    • Sinus node dysfunction (SND) is a common cardiac arrhythmia.
    • Permanent pacemakers are a standard treatment for SND-related bradycardia.
    • The long-term effects of pacemakers on supraventricular rhythms in SND patients require further investigation.

    Purpose of the Study:

    • To evaluate the efficacy of permanent endocardial pacemakers in patients with sinus node dysfunction.
    • To assess the impact of pacemaker therapy on underlying heart rhythms and associated complications.
    • To investigate the role of atrial fibrillation in the natural history of sinus node dysfunction.

    Main Methods:

    • Thirty-three patients with diagnosed sinus node dysfunction receiving permanent endocardial pacemakers were enrolled.

    Related Experiment Videos

  • Pacemaker function was externally inhibited to study underlying heart rate and rhythm.
  • Patients were monitored for the development of atrial fibrillation and embolic events.

    • Main Results:

    • Pacemaker therapy successfully controlled syncopal episodes caused by bradycardia.
    • Atrial fibrillation developed in 7 of 29 evaluated patients, resolving sinus node dysfunction.
    • Embolic complications were noted as a significant factor in morbidity and mortality.
    • Recurrent tachycardia episodes were not improved by pacemaker therapy.

    Conclusions:

    • Permanent pacemakers are effective for bradycardia in sinus node dysfunction but do not resolve tachycardia.
    • The development of atrial fibrillation can be a terminal event for sinus node dysfunction.
    • Embolic complications associated with supraventricular rhythm changes pose a significant risk in these patients.