Synaptic structure and function in transgenic APP mice
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Conditional Genetic Transsynaptic Tracing in the Embryonic Mouse Brain
Published on: December 22, 2014
1Department of Neurology, University of Minnesota, Box 295 UMHC, 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA. hsiao005@tc.umn.edu
Annals of the New York Academy of Sciences
|February 24, 2001
Abstract:
Efforts using transgenic mice are being made to understand the molecular and structural basis for dementia in Alzheimer's disease. Transgenic mice 12 to 18 months of age with amyloid plaques and impaired cognition show no neuronal or synaptic loss in the CA1 hippocampal subfield. Electrophysiological studies may yield new insights.
