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A novel VIP responsive gene. Activity dependent neuroprotective protein
I Gozes1, R Zamostiano, A Pinhasov
1Department of Clinical Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. igozes@post.tau.ac.il
Annals of the New York Academy of Sciences
|February 24, 2001
Summary
Activity-dependent neuroprotective protein (ADNP) is a glial protein with a potent neuroprotective peptide (NAP). VIP increases ADNP expression, suggesting ADNP is part of VIP-mediated neuroprotection.
Area of Science:
- Neuroscience
- Molecular Biology
- Glial Cell Biology
Background:
- Activity-dependent neuroprotective protein (ADNP) is a glial-derived protein.
- ADNP contains a femtomolar active neuroprotective peptide, NAPVSIPQ (NAP).
- Vasoactive intestinal peptide (VIP) exhibits neuroprotective properties.
Purpose of the Study:
- To investigate the relationship between VIP and ADNP.
- To explore ADNP's role in VIP-induced neuroprotection.
Main Methods:
- Analysis of ADNP mRNA levels in astrocytes following VIP treatment.
- Assessment of ADNP distribution in the mouse brain.
Main Results:
- VIP treatment induced a two- to threefold increase in ADNP mRNA in astrocytes.
- ADNP was found to be widely distributed in the mouse hippocampus, cerebellum, and cerebral cortex.
- VIP's neuroprotective activity may involve the activation of glial proteins like ADNP.
Conclusions:
- ADNP is a VIP-responsive gene.
- ADNP, particularly its NAP peptide, may be integral to the VIP-mediated neuroprotection pathway.
- ADNP might interact with other macromolecules to exert its protective effects.