Related Experiment Video

Updated: Oct 9, 2026

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples
10:13

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples

Published on: December 2, 2022

A spectrophotometric study of the pH-dependent and DNA binding properties of topotecan

S E Miller1, D S Pilch

  • 1Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA.

Annals of the New York Academy of Sciences
|February 24, 2001
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

Quantitative Detection of DNA-Protein Crosslinks and Their Post-Translational Modifications
10:12

Quantitative Detection of DNA-Protein Crosslinks and Their Post-Translational Modifications

Published on: April 21, 2023

Determining the Thermodynamic and Kinetic Association of a DNA Aptamer and Tetracycline Using Isothermal Titration Calorimetry
06:02

Determining the Thermodynamic and Kinetic Association of a DNA Aptamer and Tetracycline Using Isothermal Titration Calorimetry

Published on: August 23, 2022

Related Experiment Videos

Last Updated: Oct 9, 2026

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples
10:13

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples

Published on: December 2, 2022

Quantitative Detection of DNA-Protein Crosslinks and Their Post-Translational Modifications
10:12

Quantitative Detection of DNA-Protein Crosslinks and Their Post-Translational Modifications

Published on: April 21, 2023

Determining the Thermodynamic and Kinetic Association of a DNA Aptamer and Tetracycline Using Isothermal Titration Calorimetry
06:02

Determining the Thermodynamic and Kinetic Association of a DNA Aptamer and Tetracycline Using Isothermal Titration Calorimetry

Published on: August 23, 2022

Related Concept Videos

DNA Topoisomerases02:02

DNA Topoisomerases

Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types.  Type I...
Inhibitors of Bacterial DNA Synthesis01:28

Inhibitors of Bacterial DNA Synthesis

Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These antibiotics are selectively...

Articles linked to this work by shared authors, journal, and citation graph.

Genome-wide Gene-by-Sex Interaction Studies Identify Novel Nonsyndromic Orofacial Clefts Risk Locus.

Journal of dental research·2021

Executive functioning in low birth weight children entering kindergarten.

Journal of perinatology : official journal of the California Perinatal Association·2017

Associations between birthweight and overweight and obesity in school-age children.

Pediatric obesity·2017

A comparative analysis of experimental selection on the stickleback pelvis.

Journal of evolutionary biology·2017

Hemorrhagic Herpes Simplex Virus Type 1 Nephritis: An Unusual Cause of Acute Allograft Dysfunction.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016

Expression of a mitochondrial progesterone receptor in human spermatozoa correlates with a progestin-dependent increase in mitochondrial membrane potential.

Andrology·2014

A Thermodynamic Analysis of Enhanced Metastability in Isochoric Supercooled Liquids.

Annals of the New York Academy of Sciences·2026

Structure of Musical Dislikes: Findings From Multiple Genres and Countries.

Annals of the New York Academy of Sciences·2026

A DRACH Observed/Expected Metric Reveals the Evolutionary Landscape of Epitranscriptomic Regulation Across Bilateria.

Annals of the New York Academy of Sciences·2026

Evolutionary Background of Precise Vocal-Respiratory Temporal Coordination in Human Infants.

Annals of the New York Academy of Sciences·2026

Tropical Easterly Waves in the Tropical North Atlantic Basin.

Annals of the New York Academy of Sciences·2026

Dynamic Adaptation Responses to Auditory Perturbations During Walking in Multiple Sclerosis With Progressive Subtypes.

Annals of the New York Academy of Sciences·2026

LRRC57/RABIN is a presynaptic inhibitor of Rab GTPases in glutamatergic neurons.

bioRxiv : the preprint server for biology·2026

A scoping review of adverse events associated with concomitant beta-adrenoreceptor blockers and selective serotonin reuptake inhibitors.

British journal of clinical pharmacology·2026

Optimal drug, dose and duration of antipsychotic therapy following amphetamine and cannabis-induced psychosis: A systematic review.

The Australian and New Zealand journal of psychiatry·2026

Effects of opioids and stimulants on the respiratory system.

European respiratory review : an official journal of the European Respiratory Society·2026

Behavior change, health, and health disparities 2026: Contributions of behavioral pharmacology and behavioral economics to addiction science.

Preventive medicine·2026

ToxMamba: a novel method for toxic peptide prediction based on the fusion of pretrained embeddings and multi-scale state space models.

Briefings in bioinformatics·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us