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Causes of late mortality in patients with disabling intermittent claudication
M Kobayashi1, S Shindo, K Kubota
1Second Department of Surgery, Yamanashi Medical University, Japan. masak@res.yamanashi-med.ac.jp
Insights
Patients with intermittent claudication face a poorer long-term prognosis. Key causes of late death include ischemic heart disease, malignancy, and cerebrovascular accidents, necessitating age-specific care strategies.
Area of Science:
- Vascular Medicine
- Cardiovascular Epidemiology
- Oncology
Background:
- Intermittent claudication (IC) is associated with a worse long-term prognosis compared to the general population.
- Understanding the causes of late mortality in IC patients is crucial for improving outcomes.
Purpose of the Study:
- To retrospectively review the outcomes of hospitalized patients with intermittent claudication.
- To identify the primary causes of late death in this patient cohort.
Main Methods:
- Retrospective review of patient records for individuals admitted with intermittent claudication.
- Analysis of cumulative survival rates at various time points (1, 3, 5, and 10 years).
- Categorization and comparison of major causes of death.
Main Results:
- Cumulative survival rates at 1, 3, 5, and 10 years were 94.6%, 79.4%, 67.3%, and 37.4%, respectively.
- Ischemic heart disease, malignancy, and cerebrovascular accident were equally prevalent causes of late death.
- Younger patients were more likely to die from ischemic heart disease, while older patients succumbed to cerebrovascular accidents; malignancies affected all age groups similarly.
Conclusions:
- Intermittent claudication patients exhibit significantly reduced long-term survival.
- Age-specific mortality patterns highlight the need for tailored management strategies.
- Targeted interventions addressing ischemic heart disease, malignancies, and cerebrovascular events are essential for this population.
Abstract:
The long-term prognosis of patients suffering from intermittent ischemic claudication is reportedly worse than that of the normal population. The outcome of patients with ischemic claudication admitted to hospital was reviewed retrospectively to identify the causes of late death. The cumulative survival rates for patients with claudication were 94.6% at 1 year, 79.4% at 3 years, 67.3% at 5 years and 37.4% at 10 years. The 3 major causes of death, that is, ischemic heart disease, malignancy, and cerebrovascular accident, were equally common. The younger patients tended to die of ischemic heart disease, whereas the older patients died of cerebrovascular accidents. Malignancies caused a similar number of late deaths in all age groups. These results suggest that specific care should be given to patients with intermittent claudication based on the age-related causes of death.