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Related Experiment Videos

Plasma amino acid pattern in pellagra.

Ghafoorunissa, B S Rao

    The American Journal of Clinical Nutrition
    |April 1, 1975
    PubMed
    Summary

    This study found that leucine does not lower plasma tryptophan levels in pellagra patients. Therefore, plasma tryptophan may not be a reliable indicator for diagnosing pellagra.

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    Area of Science:

    • Biochemistry
    • Nutritional Science
    • Clinical Medicine

    Background:

    • Pellagra is a disease often linked to niacin deficiency, but the role of amino acids like leucine and tryptophan is not fully understood.
    • Previous hypotheses suggested leucine might induce pellagra by affecting tryptophan levels.

    Purpose of the Study:

    • To investigate the relationship between plasma amino acid levels and pellagra.
    • To determine if leucine administration affects plasma tryptophan levels in normal subjects.
    • To assess the reliability of plasma tryptophan levels as a diagnostic marker for pellagra.

    Main Methods:

    • Measured plasma free amino acid levels in pellagra patients and compared them to control groups from different socioeconomic statuses.
    • Administered L-leucine to normal subjects and monitored changes in plasma tryptophan levels.

    Main Results:

    • Plasma tryptophan levels in pellagra patients showed significant variation and overlapped with those of low socioeconomic controls.
    • L-leucine administration to normal subjects did not alter plasma tryptophan levels.

    Conclusions:

    • The pellagragenic effect of leucine is unlikely to be mediated by alterations in circulating tryptophan levels.
    • Low plasma tryptophan levels alone may not be a sufficient biochemical marker for diagnosing pellagra.

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