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Related Experiment Videos

Platelet morphology after aspirin.

L F Fajardo

    American Journal of Clinical Pathology
    |April 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Aspirin (ASA) ingestion did not cause platelet abnormalities seen in malaria patients. While ASA reduced platelet size and impaired function, it did not create the specific inclusions observed in malaria.

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    Area of Science:

    • Hematology
    • Pharmacology
    • Infectious Diseases

    Background:

    • Morphologic platelet abnormalities, including inclusions, are observed in acute malaria.
    • The potential role of aspirin (ASA) in causing these abnormalities is unknown.

    Purpose of the Study:

    • To investigate whether aspirin ingestion contributes to the morphologic platelet abnormalities found in malaria patients.

    Main Methods:

    • Examined thrombocytes from 14 healthy men before and after ingesting 2 Gm. of aspirin.
    • Assessed platelet size, ultrastructure, bleeding time (in vivo), and aggregation (in vitro).

    Main Results:

    • A significant decrease in platelet size was observed post-aspirin ingestion.
    • No ultrastructural alterations in circulating platelets were detected after aspirin.

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  • Functional impairment was evident through increased bleeding time and altered aggregation patterns.

    • Conclusions:

    • Aspirin ingestion does not cause the inclusions or other morphologic abnormalities observed in the thrombocytes of malaria patients.
    • Aspirin affects platelet size and function but not ultrastructure in a way that mimics malaria-related changes.