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Platelet morphology after aspirin

L F Fajardo

    American Journal of Clinical Pathology
    |April 1, 1975
    PubMed

    Insights

    Aspirin (ASA) ingestion did not cause platelet abnormalities seen in malaria patients. While ASA reduced platelet size and impaired function, it did not create the specific inclusions observed in malaria.

    Area of Science:

    • Hematology
    • Pharmacology
    • Infectious Diseases

    Background:

    • Morphologic platelet abnormalities, including inclusions, are observed in acute malaria.
    • The potential role of aspirin (ASA) in causing these abnormalities is unknown.

    Purpose of the Study:

    • To investigate whether aspirin ingestion contributes to the morphologic platelet abnormalities found in malaria patients.

    Main Methods:

    • Examined thrombocytes from 14 healthy men before and after ingesting 2 Gm. of aspirin.
    • Assessed platelet size, ultrastructure, bleeding time (in vivo), and aggregation (in vitro).

    Main Results:

    • A significant decrease in platelet size was observed post-aspirin ingestion.
    • No ultrastructural alterations in circulating platelets were detected after aspirin.
    • Functional impairment was evident through increased bleeding time and altered aggregation patterns.

    Conclusions:

    • Aspirin ingestion does not cause the inclusions or other morphologic abnormalities observed in the thrombocytes of malaria patients.
    • Aspirin affects platelet size and function but not ultrastructure in a way that mimics malaria-related changes.

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