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[Influenza].

L Calza1, E Briganti, R Manfredi

  • 1Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, Università, Bologna.

Recenti Progressi in Medicina
|February 24, 2001
PubMed
Summary
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Influenza outbreaks pose significant health and economic burdens. Recent advances in live attenuated vaccines and neuraminidase inhibitor antivirals offer improved prevention and treatment strategies for influenza.

Area of Science:

  • Virology and immunology
  • Epidemiology of infectious diseases

Context:

  • Influenza outbreaks cause significant morbidity, mortality, and economic losses globally.
  • High genetic variability of influenza viruses (antigenic drift and shift) complicates control efforts.
  • Existing control measures like inactivated vaccines and adamantanes have limitations.

Purpose:

  • To review recent advances in influenza prevention and control.
  • To highlight the efficacy of new therapeutic and prophylactic strategies against influenza.

Summary:

  • New live attenuated, cold-adapted, trivalent intranasal vaccines demonstrate high efficacy in children against influenza A (H3N2) and B.
  • Neuraminidase inhibitor antiviral drugs, zanamivir and oseltamivir, shorten symptom duration by 1-2 days.

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  • These developments represent significant progress in managing influenza.

    • Impact:

    • Novel vaccines and antivirals are expected to modify future approaches to influenza treatment and prevention.
    • Improved control measures can reduce the public health and economic impact of influenza outbreaks.
    • Enhanced strategies are crucial for protecting high-risk populations and the general populace.