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Bone turnover in hyperthyroidism before and after thyrostatic management.

G C Isaia1, C Roggia, D Gola

  • 1Department of Internal Medicine, University of Turin, Italy.

Journal of Endocrinological Investigation
|February 24, 2001
PubMed
Summary
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Hyperthyroidism elevates bone turnover markers, indicating increased bone formation and resorption. Treatment with methimazole normalizes these markers and improves bone mineral density, suggesting their utility in monitoring hyperthyroid bone disease.

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Biochemistry

Background:

  • Hyperthyroidism is linked to heightened osteoblastic and osteoclastic activity.
  • Patients often exhibit low bone mineral density and elevated bone turnover rates.

Purpose of the Study:

  • To investigate trends in bone formation and resorption markers.
  • To assess these markers in 12 female hyperthyroid patients before and after thyroid activity normalization via methimazole treatment.

Main Methods:

  • Measurements included total alkaline phosphatase (ALP), bone alkaline phosphatase (BALP), PICP, osteocalcin (BGP), ICTP, uOHP/uCreat, uCa/uCreat, and D-Pyr.
  • Data collected at baseline, and 1 and 6 months post-treatment.

Main Results:

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  • All measured bone turnover markers were significantly elevated in hyperthyroid patients compared to controls.
  • Post-treatment, bone formation markers (ALP, BALP, PICP) showed an initial slight increase followed by a significant decrease.
  • Resorption markers (uOHP/uCreat, D-Pyr) significantly decreased, and lumbar bone mineral density (BMD) increased after 6 months of normalized thyroid activity.

    • Conclusions:

    • Both bone formation and resorption markers effectively assess pathological bone turnover in hyperthyroidism.
    • These markers can monitor the impact of antithyroid treatment on bone health.
    • Consideration of antiresorption therapy may be indicated based on marker trends.