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Related Experiment Videos

Spinal tanycytic ependymomas.

N Kawano1, S Yagishita, H Oka

  • 1Isobe Clinic, Sagamihara, Kanagawa, Japan. nkawano@mil.allnet.ne.jp

Acta Neuropathologica
|February 24, 2001
PubMed
Summary
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Spinal tanycytic ependymomas are rare tumors presenting as gradual paraparesis. These tumors, characterized by spindle cells, are often found in the cervical spinal cord and should be considered in the differential diagnosis of central nervous system spindle cell tumors.

Area of Science:

  • Neuro-oncology
  • Spinal Cord Pathology
  • Neurosurgery

Background:

  • Tanycytic ependymomas are a rare subtype of ependymoma, typically arising in the spinal cord.
  • Understanding their distinct histological and clinical features is crucial for accurate diagnosis and management.

Observation:

  • Reported are three cases of spinal tanycytic ependymoma in adult patients presenting with progressive paraparesis.
  • Magnetic resonance imaging revealed well-circumscribed, enhancing spinal cord tumors.
  • Histological examination showed monotonous spindle cells with eosinophilic processes, focal perivascular pseudorosettes, and strong immunopositivity for GFAP, S-100, and vimentin.

Findings:

  • Ultrastructural analysis revealed abundant intermediate filaments and microtubules, with occasional desmosomes and microlumina.

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  • Complete gross tumor resection was achieved in all three cases.
  • Patients remained recurrence-free at 2 to 9 years postoperatively.

    • Implications:

    • Spinal tanycytic ependymoma appears to occur more frequently in the spinal cord, particularly the cervical region.
    • Given its histological similarity to pilocytic astrocytoma and schwannoma, it warrants inclusion in the differential diagnosis of benign spinal cord spindle cell tumors.
    • Successful surgical outcomes highlight the importance of early and accurate diagnosis.