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Do matrix metalloproteinases MMP-2 and MMP-9 (gelatinases) play a role in renal development, physiology and

B Lelongt, B Legallicier, R Piedagnel

    Current Opinion in Nephrology and Hypertension
    |February 24, 2001
    PubMed

    Insights

    Matrix metalloproteinases (MMPs), specifically MMP-2 and MMP-9, are crucial for development and cell invasion. New research using MMP-9-deficient mice offers fresh insights into their complex roles in kidney development and disease.

    Area of Science:

    • Biochemistry
    • Developmental Biology
    • Nephrology

    Background:

    • Matrix metalloproteinases (MMPs), including MMP-2 and MMP-9 (gelatinases), are key enzymes in extracellular matrix remodeling.
    • These enzymes are recognized for their roles in cell invasion, embryonic development, and organogenesis.
    • Emerging evidence points to their involvement in renal development, tubule physiology, and glomerular pathophysiology.

    Discussion:

    • This editorial critically examines recent, often controversial, findings regarding MMP-2 and MMP-9 functions in the kidney.
    • Particular attention is given to data derived from studies utilizing MMP-9-deficient mouse models.
    • These studies challenge and refine our understanding of gelatinase roles in renal contexts.

    Key Insights:

    • MMP-9 deficiency significantly impacts renal development and function, revealing novel roles for this enzyme.
    • Gelatinases are implicated in both normal kidney development and the progression of renal pathologies.
    • Controversial data necessitates a re-evaluation of established functions of MMP-2 and MMP-9 in renal physiology.

    Outlook:

    • Further research is needed to fully elucidate the specific mechanisms by which MMP-2 and MMP-9 influence renal tubule and glomerular function.
    • Investigating the therapeutic potential of targeting MMPs in kidney disease requires careful consideration of their dual roles.
    • Future studies should aim to reconcile conflicting data and establish a definitive understanding of gelatinase functions in the kidney.

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