A multicenter collaborative study on the risk factors of cardiac sequelae due to Kawasaki disease: a one-year

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I Oki1, S Tanihara, T Ojima

  • 1Department of Public Health, Jichi Medical School, Tochigi, Japan. i-oki@jichi.ac.jp

Acta Paediatrica (Oslo, Norway : 1992)
|February 24, 2001
PubMed

Insights

Most Kawasaki disease cardiac sequelae resolve within one year. Low serum albumin levels are a significant risk factor for persistent cardiac issues in children after Kawasaki disease.

Area of Science:

  • Pediatrics
  • Cardiology
  • Rheumatology

Background:

  • Kawasaki disease is a leading cause of acquired heart disease in children.
  • Cardiac sequelae are a major concern following Kawasaki disease.
  • Understanding the long-term cardiac outcomes and risk factors is crucial for patient management.

Purpose of the Study:

  • To determine the prevalence of cardiac sequelae one year after Kawasaki disease onset.
  • To identify risk factors associated with the development and persistence of cardiac sequelae.

Main Methods:

  • A nationwide survey identified 87 hospitals for a retrospective study.
  • 1594 patients diagnosed with Kawasaki disease in 1996 were included.
  • Cardiac sequelae within one year of onset were assessed via mail survey.

Main Results:

  • The prevalence of cardiac sequelae decreased from 10.2% at one month to 4.2% at one year.
  • Approximately 60.7% of initial cardiac sequelae resolved within one year.
  • Low serum albumin levels were identified as a significant risk factor for persistent cardiac sequelae.
  • Higher prevalence was observed in males and in younger (<1 year) and older (≥5 years) age groups.

Conclusions:

  • A significant proportion of Kawasaki disease-related cardiac sequelae resolve within one year.
  • Low serum albumin is a key predictor of persistent cardiac sequelae.
  • Early identification and management of risk factors like low albumin may improve long-term cardiac outcomes.
Abstract

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