Acyclovir-resistant varicella infection with atypical lesions in a non-HIV leukemic infant
N Crassard1, A L Souillet, F Morfin
1Department of Pediatric Hematology and Immunology, H pital Debrousse, Lyon, France.
Acta Paediatrica (Oslo, Norway : 1992)
|February 24, 2001
Abstract
Unlabelled:
An HIV-negative infant presented with VZV primary infection during the maintenance therapy for megakaryoblastic leukaemia. The lesions were initially vesicular and necrotic but became verrucous and hyperkeratotic. A clinical resistance to acyclovir was suspected and confirmed by histologic and virologic studies. The patient was successfully treated by foscarnet.
Conclusion:
resistance of VZV to acyclovir may occur after a short treatment in a non-AIDS patient.
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