Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Placental diffusing capacity in unanesthetized rabbits.

E Rocco, T R Bennett, G G Power

    The American Journal of Physiology
    |February 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Excitation Spectra of the ^{12}C(p,d) Reaction near the η^{'}-Meson Emission Threshold Measured in Coincidence with High-Momentum Protons.

    Physical review letters·2026
    Same author

    First Proton-Induced Cross Sections on a Stored Rare Ion Beam: Measurement of ^{118}Te(p,γ) for Explosive Nucleosynthesis.

    Physical review letters·2025
    Same author

    Production and separation of positron emitters for hadron therapy at FRS-Cave M.

    Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms·2023
    Same author

    A strange case of Transthyretin Cardiac Amyloidosis in the Elderly: a diagnostic challenge.

    La Clinica terapeutica·2023
    Same author

    The applications of Wearable Cardioverter Defibrillators in Heart Failure and beyond.

    La Clinica terapeutica·2023
    Same author

    Reel syndrome: a rare presentation of a rare cause of cardiac resynchronization malfunction.

    La Clinica terapeutica·2022
    Same journal

    Blood coagulation in fish.

    The American journal of physiology·2011
    Same journal

    Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

    The American journal of physiology·2010
    Same journal

    The inactivation of placental toxin by human serum.

    The American journal of physiology·2010
    Same journal

    Adrenal function following ovariectomy in the rat.

    The American journal of physiology·2010
    Same journal

    Capillary permeability; perfusion of frog and guinea pig hind limbs.

    The American journal of physiology·2010
    Same journal

    Evaluation of protective measures against sunburn.

    The American journal of physiology·2010
    See all related articles

    This study measured placental diffusing capacity for carbon monoxide (CO) in rabbits. Unanesthetized rabbits showed a significantly higher CO placental transfer rate than previously reported in other species.

    Area of Science:

    • Physiology
    • Perinatal Biology
    • Respiratory Physiology

    Background:

    • The placental transfer of gases like carbon monoxide (CO) is crucial for fetal development.
    • Previous measurements of placental diffusing capacity for CO were primarily conducted in anesthetized animals, potentially introducing confounding factors.

    Purpose of the Study:

    • To determine the placental diffusing capacity of carbon monoxide (CO) in unanesthetized rabbits.
    • To establish baseline CO transfer rates in a non-anesthetized mammalian model.

    Main Methods:

    • 18 near-term rabbits were administered a standard dose of CO.
    • Maternal and fetal blood samples were collected at various intervals (5 min to 4 h).
    • Carboxyhemoglobin saturation (HbCO) was analyzed to quantify CO transfer across the placenta.

    Related Experiment Videos

    Main Results:

    • Maternal HbCO rapidly increased and stabilized post-CO administration.
    • Fetal HbCO rose as CO crossed the placenta, reaching maternal levels within 15 minutes.
    • Fetal HbCO became 1.7-fold higher than maternal levels after 1 hour, indicating significant transfer.
    • The calculated placental diffusing capacity for CO was 2.3 ml/(min·mmHg·kg).

    Conclusions:

    • The placental diffusing capacity for CO in unanesthetized rabbits is approximately fourfold higher than reported in anesthetized sheep and dogs.
    • This suggests significant species-specific differences or effects of anesthesia and surgical preparation on CO placental transfer.
    • Further research is needed to elucidate the precise factors influencing these observed differences.