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[Breast angiosarcoma].

F Sandoval Guerrero1, M Moreno Möller, C Avecilla Guerrero

  • 1Unidad de Tumores Mamarios, Hospital General de México.

Ginecologia Y Obstetricia De Mexico
|February 24, 2001
PubMed
Summary

This case report highlights a rare mammary angiosarcoma in a young female. Early suspicion and advanced imaging like MRI are crucial for timely diagnosis and treatment of this aggressive breast cancer.

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Area of Science:

  • Oncology
  • Pathology
  • Radiology

Background:

  • Mammary angiosarcoma is a rare and aggressive malignant vascular neoplasm of the breast.
  • It often presents as a rapidly growing mass, sometimes with overlying skin changes.

Observation:

  • A 28-year-old female presented with a 2-year history of progressive left breast enlargement and a painless mass with violaceous macular lesions.
  • Mammography was inconclusive, but contrast-enhanced MRI revealed a large (10.5 x 8.5 cm) vascular mass involving the superior breast and extending to the pectoral fascia.
  • Initial biopsy suggested low-grade angiosarcoma, with final histopathology confirming intermediate-grade mammary angiosarcoma.

Findings:

  • Immunohistochemistry was positive for Factor VIII, Ulex Europaeus, and CD31, supporting the diagnosis of angiosarcoma.
  • The tumor occupied a significant portion of the breast but did not invade the pectoral muscle.

Implications:

  • A high index of suspicion is essential for the early diagnosis of mammary angiosarcoma.
  • Magnetic resonance imaging plays a vital role in characterizing the extent of the tumor and guiding clinical management, including surgical approach.

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