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Related Experiment Videos

Imipramine and electrocardiographic abnormalities in hyperactive children.

B G Winsberg, S Goldstein, L E Yepes

    The American Journal of Psychiatry
    |May 1, 1975
    PubMed
    Summary

    Imipramine treatment in children may cause electrocardiographic abnormalities, including atrioventricular block. Careful clinical monitoring is essential during imipramine pharmacotherapy for behavior disorders.

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    Area of Science:

    • Pediatric Cardiology
    • Child Psychiatry
    • Clinical Pharmacology

    Background:

    • Imipramine is a tricyclic antidepressant used for behavior disorders in children.
    • Electrocardiographic (ECG) changes have been reported with tricyclic antidepressants, but data in pediatric populations are limited.

    Purpose of the Study:

    • To report cases of ECG abnormalities in children treated with imipramine.
    • To assess the relationship between imipramine plasma levels and ECG changes.

    Main Methods:

    • Observational case series of seven children aged 7-10 years receiving imipramine.
    • Electrocardiograms were performed during imipramine pharmacotherapy.
    • Imipramine plasma levels were measured at steady state.

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    Main Results:

    • Seven children exhibited ECG abnormalities.
    • Three children developed first-degree atrioventricular block.
    • No direct correlation was found between imipramine plasma levels and the severity of ECG changes.

    Conclusions:

    • Imipramine pharmacotherapy can lead to ECG abnormalities in children.
    • Close clinical surveillance is necessary for children undergoing imipramine treatment.
    • Further research is needed to understand the long-term cardiac effects.