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[Treatment of experimental corneal injuries by dioxidine and urotropin solutions]
Abstract:
The efficiency of 1% dioxidine and 5% urotropin solutions in suppurative penetrating corneal wounds was studied in 2 experimental series on 54 rabbits. In series A toxic effects of these drugs on eyeball tissues were studied on 6 rats, in series B drug effects were studied on a model of suppurative penetrating corneal wounds. A 21-day course of therapy with these drugs (instillations and subconjunctival parabulbar injections) caused no toxic changes in ocular tissues. Therapy with 1% dioxidine and 5% urotropin accelerated clinical cure by 4-6 days in comparison with other methods of treatment. Clinical cure was observed 3-5 days sooner after combined use of both drugs in comparison with their individual application, during during combined use their antibacterial effect was synergistic. Hence, a combination of 1% dioxidine and 5% urotropin solutions is an effective method for treating suppurative penetrating wounds of the cornea.
Insights
A combination of dioxidine and urotropin effectively treats suppurative penetrating corneal wounds. This therapy accelerates healing by 4-6 days with no observed toxic effects on ocular tissues.
Area of Science:
- Ophthalmology
- Veterinary Medicine
- Pharmacology
Background:
- Suppurative penetrating corneal wounds pose a significant clinical challenge.
- Effective antimicrobial therapy is crucial for preventing vision loss.
Purpose of the Study:
- To evaluate the efficacy and safety of 1% dioxidine and 5% urotropin solutions for treating suppurative penetrating corneal wounds in rabbits.
- To determine the synergistic effects of combining these two agents.
Main Methods:
- Two experimental series were conducted on 54 rabbits with suppurative penetrating corneal wounds.
- Toxic effects on ocular tissues were assessed in a separate study on 6 rats.
- Treatment involved instillations and subconjunctival/parabulbar injections over a 21-day period.
Main Results:
- Neither 1% dioxidine nor 5% urotropin caused toxic changes in ocular tissues after a 21-day treatment course.
- Both agents individually accelerated clinical cure by 4-6 days compared to other methods.
- Combined therapy resulted in clinical cure 3-5 days sooner than individual drug application, indicating synergistic antibacterial activity.
Conclusions:
- A combination of 1% dioxidine and 5% urotropin is a safe and effective treatment for suppurative penetrating corneal wounds.
- The synergistic action of these drugs enhances their therapeutic efficacy.
- This combined approach offers a promising strategy for accelerated corneal wound healing.