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Related Experiment Videos

[Hypophosphatemic oncogenic osteomalacia].

J Mátyus1, B Szebenyi, P Rédl

  • 1Debreceni Egyetem, Orvos-, Egészségtudományi Centrum, Altalános Orvostudományi Kar, I. Belklinika.

Orvosi Hetilap
|February 24, 2001
PubMed
Summary

A rare case of oncogenic osteomalacia, a bone disease, was identified in Hungary. A gingival tumor removal normalized phosphate levels, resolving the condition and highlighting the tumor

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Area of Science:

  • Endocrinology
  • Oncology
  • Nephrology

Background:

  • Oncogenic osteomalacia is a rare paraneoplastic syndrome causing hypophosphatemia.
  • It is characterized by renal phosphate wasting and bone demineralization.
  • This case highlights a unique presentation and management in Hungary.

Observation:

  • A 19-year-old sportsman presented with pathological hip fracture due to hypophosphatemic osteomalacia.
  • Despite prolonged treatment with calcitriol and phosphate, hypophosphatemia persisted.
  • A 1.5 cm gingival tumor (epulis) was discovered and surgically removed.

Findings:

  • Serum phosphate levels normalized rapidly post-tumor removal, without further treatment.
  • Histological examination revealed epulis with fibroblast and vascular proliferation, a novel finding in oncogenic osteomalacia.

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  • Bone pain resolved, and bone density normalized within a year.

    • Implications:

    • Oncogenic osteomalacia should be considered in atypical hypophosphatemic osteomalacia cases.
    • Thorough dental examinations are crucial for identifying underlying tumors.
    • Radical surgical removal of tumor-like growths and postoperative phosphate monitoring are essential.