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A bi-allelic VNTR in the human TNFR2 (p75) gene promoter
1Division of Transplantation Sciences, University of Bristol, Homoeopathic Hospital Site, Cotham, Bristol, BS6 6JU, UK. J.Keen@bris.ac.uk
Genes and Immunity
|February 24, 2001
Abstract:
We describe a bi-allelic VNTR polymorphism within a 42 bp region in the promoter of the tumour necrosis factor receptor 2 gene (TNFR2). Within this region there are one (Allele 1) or two (Allele 2) repeats of a 15 bp sequence, 5'-GCCGGGC AGGTGGAG-3'. Allele frequencies observed in a Caucasian population were 0.3 (Allele 1) and 0.7 (Allele 2).