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Cytokine gene polymorphism in human disease: on-line databases
J Bidwell1, L Keen, G Gallagher
1Department of Pathology and Microbiology, University of Bristol, Homoeopathic Hospital Site, Cotham, Bristol BS6 6JU, UK.
Genes and Immunity
|February 24, 2001
Summary
Genetic variations in cytokine genes influence immune responses and disease susceptibility. This review examines how cytokine gene polymorphism impacts T helper cell (TH1/TH2) activity and disease pathology.
Area of Science:
- Immunology
- Genetics
- Molecular Biology
Background:
- Cytokine production profiles in T helper 1 (TH1) and T helper 2 (TH2) cells modulate infectious, autoimmune, and malignant diseases.
- Interindividual variations in these profiles are linked to genetic differences, specifically allelic polymorphism in cytokine gene regulatory regions.
Purpose of the Study:
- To review existing research on the association between cytokine gene polymorphism and disease.
- To explore the relationship between genetic variations, cytokine gene expression, and disease susceptibility and severity.
Main Methods:
- Literature review of studies investigating cytokine gene polymorphism.
- Analysis of research linking genetic variations to in vitro cytokine gene expression.
- Examination of studies correlating polymorphism with disease susceptibility and clinical outcomes.
Main Results:
- Evidence suggests a significant link between cytokine gene polymorphism and the modulation of immune responses.
- Specific polymorphisms are associated with altered cytokine expression levels.
- These genetic variations correlate with susceptibility and clinical severity in various diseases.
Conclusions:
- Cytokine gene polymorphism is a key factor influencing immune system function and disease pathology.
- Understanding these genetic associations can aid in predicting disease risk and severity.
- Further research is warranted to fully elucidate the complex interplay between cytokine genetics and human health.