Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Animal Mitochondrial Genetics

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

Meiosis vs. Mitosis

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Development of the Oral Microbiota

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

On the propagation of error in air pollution measurements.

Environmental monitoring and assessment·2013

Same author

Epizootics of sudden death in tammar wallabies (Macropus eugenii) associated with an orbivirus infection.

Australian veterinary journal·2012

Same author

Chronic treatment of female tammar wallabies with deslorelin implants during pouch life: effects on reproductive maturation.

Reproduction, fertility, and development·2012

Same author

Particle collection efficiency in a venturi scrubber: comparison of experiments with theory.

Environmental science & technology·2011

Same author

Is a relatively high pre-spinal heart rate associated with reduced efficacy of prophylactic vasopressor during spinal anaesthesia for caesarean section?

International journal of obstetric anesthesia·2011

Same author

Retrospective study of association between choice of vasopressor given during spinal anaesthesia for high-risk caesarean delivery and fetal pH.

International journal of obstetric anesthesia·2009

Search research articles

Related Experiment Video

Updated: Jun 24, 2026

FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 24, 2011

Pathogenesis and genetics of pre-eclampsia.

J M Roberts¹, D W Cooper

¹Magee-Womens Research Institute, Pittsburgh, PA, USA.

Lancet (London, England)

|February 24, 2001

Summary

Pre-eclampsia and eclampsia are complex pregnancy disorders. Research focuses on placental-maternal interactions, vascular endothelium, oxidative stress, and genetics to understand these conditions.

Area of Science:

Obstetrics and Gynecology
Maternal-Fetal Medicine
Genetics

Background:

Pre-eclampsia and eclampsia remain poorly understood despite extensive research.
The primary cause is likely an aberration in placental-maternal tissue interaction.
The precise deviations from normal pregnancy physiology are still elusive.

Purpose of the Study:

To review current understanding of pre-eclampsia and eclampsia.
To explore the physiological changes involved in these conditions.
To identify potential genetic factors contributing to susceptibility.

Main Methods:

Literature review focusing on vascular endothelium and oxidative stress.
Analysis of genetic components in maternal and fetal genotypes.

More Related Videos

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Published on: May 17, 2024

Related Experiment Videos

Last Updated: Jun 24, 2026

FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 24, 2011

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Published on: May 17, 2024

Discussion of whole-genome mapping as a future research direction.

Main Results:

Current research emphasizes the roles of vascular endothelium dysfunction and oxidative stress.
Genetic susceptibility is acknowledged, but maternal and fetal genotype contributions are unclear.
Whole-genome mapping is proposed as a method to identify causative genes.

Conclusions:

Understanding pre-eclampsia and eclampsia requires further investigation into placental-maternal interactions.
Vascular endothelium and oxidative stress are key areas of focus.
Identifying genetic determinants is crucial for future advancements.