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Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT)

G J Kops1, B M Burgering

  • 1Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, Utrecht University, The Netherlands.

Journal of Anatomy
|February 24, 2001
PubMed

Insights

Protein kinase B (PKB) mediates diverse cellular responses through phosphoinositide 3-kinase (PI3-kinase) signaling. PKB

Area of Science:

  • Cellular signaling pathways
  • Molecular biology
  • Oncogene research

Background:

  • Protein kinase B (PKB) is a proto-oncogene.
  • PKB acts downstream of phosphoinositide 3-kinase (PI3-kinase) in cellular signaling.
  • PKB mediates various PI3-kinase dependent cellular responses.

Purpose of the Study:

  • To review the newly discovered function of PKB.
  • To highlight PKB's role in PI3-kinase dependent transcription.
  • To explain how PKB conveys diverse cellular responses.

Main Methods:

  • Literature review of PKB and PI3-kinase signaling.
  • Analysis of PKB-dependent phosphorylation of Forkhead transcription factors.
  • Focus on transcription regulation by PKB.

Main Results:

  • PKB is a key mediator of PI3-kinase signaling.
  • PKB phosphorylates Forkhead transcription factors.
  • This phosphorylation impacts PI3-kinase dependent transcription.

Conclusions:

  • PKB plays a critical role in PI3-kinase signaling.
  • PKB's function extends to regulating transcription via Forkhead factors.
  • This mechanism contributes to the diversity of cellular responses.

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