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Trovafloxacin-associated leukopenia.
F A Mitropoulos1, P B Angood, R Rabinovici
1Yale New Haven Hospital, New Haven, CT, USA.
The Annals of Pharmacotherapy
|February 24, 2001
Summary
Trovafloxacin, a synthetic fluoroquinolone antibiotic, can cause leukopenia (low white blood cell count) in trauma patients. This adverse effect resolved after discontinuing the drug, highlighting a potential safety concern.
Area of Science:
- Pharmacology
- Infectious Diseases
- Hematology
Background:
- Trovafloxacin is a broad-spectrum synthetic fluoroquinolone antibiotic.
- Fluoroquinolones are used to treat various bacterial infections.
Observation:
- A 79-year-old trauma patient developed leukopenia shortly after receiving intravenous alatrofloxacin mesylate.
- The patient's leukopenia resolved after the discontinuation of trovafloxacin.
Findings:
- This case represents the first report in English-language literature of trovafloxacin-associated leukopenia.
- The resolution of leukopenia upon drug cessation, with other causes excluded, strongly suggests an association.
Implications:
- Healthcare professionals should be aware of the potential for trovafloxacin to cause leukopenia.
- This finding underscores the importance of monitoring blood counts in patients treated with trovafloxacin, particularly trauma patients.