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Population genetics of the hypervariable locus D12S391 in Koreans
1Department of Legal Medicine, College of Medicine, Korea University, 126-1.5Ga, Anam-Dong, Sungbuk-Ku, Seoul 136-705, Korea.
International Journal of Legal Medicine
|February 24, 2001
Summary
The short tandem repeat (STR) locus D12S391 is a valuable tool for forensic identification in Koreans. This study characterized its alleles and frequencies, finding it reliable for parentage testing.
Area of Science:
- Forensic genetics
- Population genetics
Background:
- Short tandem repeat (STR) loci are crucial for human identification.
- Characterizing STR loci in diverse populations is essential for forensic applications.
Purpose of the Study:
- To investigate the hypervariable short tandem repeat (STR) locus D12S391 in a Korean population.
- To establish an allelic ladder and determine allele frequencies for forensic use.
Main Methods:
- Sequencing of 34 fragments to confirm allele structure.
- Construction of an allelic ladder with 13 sequenced alleles.
- Analysis of 595 unrelated Korean individuals and 144 Korean families.
Main Results:
- 14 alleles were detected in the Korean population, including a variant allele 19.3.
- High observed heterozygosity (0.795) and no deviation from Hardy-Weinberg equilibrium.
- Allele frequency distribution showed distinct patterns compared to other groups, with similarities to Egyptians, Yemenis, Japanese, and Rhine Caucasoids.
- No mutations were observed across 702 meioses.
Conclusions:
- The STR locus D12S391 is a robust and informative marker for forensic identification in the Korean population.
- Its genetic characteristics support its utility in parentage testing and population studies.