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Updated: Sep 16, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
Published on: February 3, 2013
Biostatistics for mixed stains: the case of tested relatives of a non-tested suspect
1Institut für Rechtsmedizin, Universität Zürich-Irchel, Winterthurerstrasse 190/Bau 52, 8057 Zürich, Switzerland. lefu@ruf.uni-freiburg.de
Abstract:
Analysis of a mixed biological stain by means of highly polymorphic VNTR systems usually reveals a profile composed of multiple markers. If the victim and one or several suspects match the profile, the evidential strength of the matches has to be very carefully analysed. The appropriate methods for the statistical analysis of DNA profiles advanced recently were limited to cases with no relationship between the tested and non-tested persons. The present paper extends the theory beyond this limitation.
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