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Updated: Aug 19, 2026

Generation of Human CD40-activated B cells
Published on: October 16, 2009
New variations in human OX40 ligand (CD134L) gene
K Hikami1, N Tsuchiya, K Tokunaga
1Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan 113-0033.
Abstract:
We found three new variations in the OX40 ligand (OX40L, CD134L) gene and its 5' upstream region. -921 (G-->A) at 5' upstream region, -19 (C-->G) at 5' untranslated region, and 202 + 25 (G-->T) at intron 2 were identified. -921 (G-->A) and 202 + 25 (G-->T) were detected in a substantial proportion of healthy Japanese individuals and were considered to be single nucleotide polymorphisms (SNPs). -19 (C-->G) was detected in only one healthy individual. There was no association between these variations and the presence of rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE).
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