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Ethanol-induced conditioned place aversion in mice.

C L Cunningham1, C M Henderson

  • 1Department of Behavioral Neuroscience and Portland Alcohol Research Center, The Oregon Health Sciences University, 97201-3098, USA. cunningh@ohsu.edu

Behavioural Pharmacology
|February 24, 2001
PubMed
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Ethanol can cause place aversion in mice when given after a stimulus, with effects varying by dose and trial length. Prior ethanol exposure and stimulus-only trials can reduce or eliminate this aversion.

Area of Science:

  • Neuroscience
  • Behavioral Pharmacology
  • Animal Models

Background:

  • Ethanol's effects on place conditioning depend on administration timing relative to stimulus exposure.
  • Ethanol administered before a stimulus typically induces place preference (CPP), while post-stimulus administration can cause place aversion (CPA).

Purpose of the Study:

  • To investigate the parametric boundaries of conditioned place aversion (CPA) induced by post-stimulus ethanol exposure in mice.
  • To compare the variables influencing CPA with those affecting ethanol-induced CPP.

Main Methods:

  • Four experiments examined CPA using different ethanol doses (1-4 g/kg) and trial durations (5-90 min).
  • The impact of prior ethanol exposure and extinction procedures (CS alone) on CPA was assessed.
  • Conditioned place preference (CPP) induced by pre-stimulus ethanol was also examined for comparison.

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Main Results:

  • CPA was dose-dependent, observed at 2 and 4 g/kg but not 1 g/kg.
  • Shorter trial durations (5-30 min) produced CPA, while longer durations (60-90 min) did not.
  • Prior ethanol exposure attenuated CPA development.
  • Extinction procedures (CS alone) eliminated both CPA and CPP.

Conclusions:

  • CPA induced by post-stimulus ethanol is influenced by dose, trial duration, prior ethanol exposure, and extinction, similar to ethanol-induced CPP.
  • These findings do not definitively clarify whether ethanol's effects are solely rewarding or encompass both rewarding and aversive components.