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On the schistosomicidal effect of triclabendazole an experimental study
1Department of Parasitology, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Abstract:
Mice were infected with S. mansoni cercariae and divided to three groups: one as control, the others were treated with a single oral dose of PZQ or TCBZ. The efficacy of the drugs was evaluated on the basis of egg excretion, number, sex and distribution of worms, oogram changes and tissue egg load. Results demonstrated that eggs disappeared from the stools in both treated groups, all worms died in the PZQ treated group while in the TCBZ group, worm production amounted to 84%. Male worms were more susceptible to the two drugs, they died earlier. On the fourth week after TCBZ, the few surviving worms returned back from their hepatic shift to the mesenteric veins. By studying the oogram pattern, it was found that PZQ had a direct lethal effect on the mature eggs; TCBZ had a lower effect on egg viability but the oogram findings indicated cessation of egg laying.
Insights
Praziquantel (PZQ) and triclabendazole (TCBZ) effectively eliminated Schistosoma mansoni eggs in mice. PZQ killed all worms, while TCBZ significantly reduced worm burden and stopped egg laying.
Area of Science:
- Parasitology
- Pharmacology
- Tropical Medicine
Background:
- Schistosomiasis mansoni is a significant parasitic disease.
- Effective drug treatments are crucial for disease control.
Purpose of the Study:
- To compare the efficacy of praziquantel (PZQ) and triclabendazole (TCBZ) against Schistosoma mansoni infection in mice.
- To evaluate the impact of these drugs on worm burden, egg excretion, and tissue egg load.
Main Methods:
- Mice infected with S. mansoni cercariae were treated with PZQ or TCBZ.
- Efficacy was assessed by monitoring egg excretion, worm counts, sex distribution, oogram changes, and tissue egg load.
Main Results:
- Both PZQ and TCBZ eliminated eggs from feces.
- PZQ eradicated all worms, whereas TCBZ resulted in 84% worm recovery.
- Male worms were more susceptible to both drugs.
- TCBZ treatment led to the cessation of egg laying, with surviving worms returning to mesenteric veins.
Conclusions:
- PZQ is highly effective, causing complete worm mortality.
- TCBZ shows significant efficacy in reducing worm burden and inhibiting egg production.
- Both drugs impact different life stages of S. mansoni, with PZQ targeting mature eggs and TCBZ affecting egg viability and laying.