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Related Experiment Videos

Baroreflex dysfunction induced by microgravity: potential relevance to postflight orthostatic intolerance.

A C Ertl1, A Diedrich, I Biaggioni

  • 1Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee 37212, USA.

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
|February 24, 2001
PubMed
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Spaceflight alters human baroreflex function. Microgravity reduces carotid sinus baroreflex but may increase aortic and cardiopulmonary baroreflexes, impacting orthostatic intolerance.

Area of Science:

  • Human physiology
  • Space medicine
  • Cardiovascular regulation

Background:

  • Microgravity induces significant adaptive changes in the human body.
  • Baroreflexes are crucial for maintaining blood pressure homeostasis.
  • Orthostatic intolerance is a common issue for astronauts post-flight.

Purpose of the Study:

  • To review changes in baroreflex function due to spaceflight or simulated microgravity.
  • To differentiate effects on high-pressure (carotid sinus, aortic arch) and low-pressure (cardiopulmonary) baroreceptors.
  • To assess the role of baroreflex alterations in microgravity-induced orthostatic intolerance.

Main Methods:

  • Analysis of studies on actual spaceflight and bed rest models.
  • Separation of baroreflex studies based on afferent pathways (carotid sinus, aortic arch, cardiopulmonary).
Keywords:
NASA Discipline Regulatory PhysiologyNon-NASA Center

Related Experiment Videos

  • Review of techniques used to assess baroreflex sensitivity, including neck suction/compression.

    • Main Results:

    • Consistent evidence shows reduced carotid-cardiac baroreflex function with microgravity exposure.
    • Studies suggest an increased gain in aortic arch and cardiopulmonary baroreflexes.
    • Limited data exists on sympathetic nervous system function and microgravity.

    Conclusions:

    • Microgravity differentially affects baroreflex pathways.
    • Altered baroreflex function is a potential contributor to orthostatic intolerance after spaceflight.
    • Further research is needed on sympathetic baroreflex function in microgravity.