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Nasal midazolam effects on childhood acute seizures
1Department of Pediatric Hematology, Dr. Sami Ulus Child Health and Disease Center, Ankara, Turkey. fisgint@ato.org.tr
Insights
Intranasal midazolam effectively treated acute seizures in children. This method is easy to administer and offers a favorable safety profile compared to other treatments.
Area of Science:
- Pediatric Neurology
- Emergency Medicine
Background:
- Acute seizures in children require rapid and effective treatment.
- Intranasal drug administration offers a non-invasive route for emergency medications.
Purpose of the Study:
- To evaluate the efficacy and safety of intranasal midazolam for treating acute seizures in pediatric patients.
Main Methods:
- Sixteen children (2 months to 14 years) with acute seizures received intranasal midazolam (0.2 mg/kg).
- Vital signs (heart rate, respiratory rate, blood pressure, oxygen saturation) were monitored post-administration.
Main Results:
- Seizure termination occurred within 5 minutes in 81.3% of patients.
- 18.7% of patients did not respond to intranasal midazolam.
- No adverse events were detailed, but safety was implied through comparison.
Conclusions:
- Intranasal midazolam is an easy and effective treatment for acute pediatric seizures.
- Midazolam presents a shorter half-life and fewer complications than diazepam.
- Nasal drop and spray formulations enhance ease of use.
Abstract:
Sixteen children, aged from 2 months to 14 years, with a diagnosis of acute seizures and seen at Dr. Sami Ulus Child Health and Disease Center, were included in this study. Midazolam (5 mg/mL) 0.2 mg/kg was administered intranasally in 30 seconds by an injector. The heart rate, respiratory rate, blood pressure, and oxygen saturation were recorded at 0, 5, and 10 minutes after administration. The seizures of three (18.7%) patients terminated within 1 minute, of seven (43.7%) patients in 1 to 2 minutes, and of three (18.7%) patients in 2 to 5 minutes. However, three (18.7%) patients did not respond to treatment. As a result, it was concluded that intranasal midazolam administration is easy and effective. The half-life of midazolam is shorter than diazepam, and midazolam has fewer complications when compared with diazepam. It is easier to use in nasal drop and spray forms.