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Mesenteric thrombosis following splenectomy.

J Balz, J P Minton

    Annals of Surgery
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Postspleen removal (splenectomy) can lead to mesenteric thrombosis, especially with high platelet counts (thrombocytosis). Prompt evaluation and anticoagulation are crucial for managing this serious complication.

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    Area of Science:

    • Vascular Surgery
    • Hematology
    • Gastroenterology

    Background:

    • Splenectomy can predispose patients to thrombotic events.
    • Thrombocytosis following splenectomy, particularly with abnormal platelet function, is a significant risk factor for thrombosis.

    Purpose of the Study:

    • To present cases of postsplenectomy mesenteric thrombosis.
    • To highlight the association between thrombocytosis and mesenteric thrombosis after splenectomy.
    • To emphasize the importance of platelet function studies and anticoagulation in managing this condition.

    Main Methods:

    • Case series presentation.
    • Review of clinical experience with postsplenectomy patients.
    • Discussion of diagnostic criteria and treatment modalities.

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    Main Results:

    • Three cases of postsplenectomy mesenteric thrombosis were identified.
    • Two of these cases were associated with thrombocytosis.
    • Abnormal platelet function was noted in conjunction with thrombocytosis.

    Conclusions:

    • Persistent thrombocytosis (>800,000/mm-3) after splenectomy warrants platelet function evaluation and anticoagulation.
    • Post-prandial abdominal pain may signal early thrombosis, requiring immediate anticoagulation.
    • Standard treatments include low-dose heparin, aspirin (ASA), and dipyridamole; surgical resection may be necessary for persistent thrombosis.