Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac allograft vasculopathy.

D Behrendt1, P Ganz, J C Fang

  • 1Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Current Opinion in Cardiology
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Transcript distribution, sequence characteristics and clinical outcomes of rare transcript types of BCR::ABL1 fusion gene-positive leukemia patients].

Zhonghua yi xue za zhi·2026
Same author

[Clinical characteristics and genotype analysis of two rare subtypes of acute myeloid leukemia].

Zhonghua yi xue za zhi·2025
Same author

[Improved detection methods and sequence characteristics of PML::RARA variant transcripts in patients with acute promyelocytic leukemia].

Zhonghua yi xue za zhi·2025
Same author

[Clinical features of acute B lymphoblastic leukemia with TAF15::ZNF384 fusion gene].

Zhonghua yi xue za zhi·2025
Same author

[Study on the inhibitory and pro-apoptotic effects of different concentrations of total tanshinone alone and in combination with tyrosine kinase inhibitors on human myeloid leukemia cell lines].

Zhonghua yi xue za zhi·2024
Same author

Effects of short-term increases in personal and ambient pollutant concentrations on pulmonary and cardiovascular function: A panel study analysis of the Multicenter Ozone Study in oldEr subjects (MOSES 2).

Environmental research·2021

Cardiac allograft vasculopathy (CAV) is a major concern after heart transplants, driven by immune and non-immune factors. Early detection and prevention are key to improving long-term transplant function and patient outcomes.

Area of Science:

  • Cardiology
  • Transplantation Immunology
  • Vascular Biology

Background:

  • Cardiac transplantation is a vital treatment for end-stage heart disease.
  • Cardiac allograft vasculopathy (CAV) significantly impacts long-term transplanted heart function.
  • CAV involves complex immunologic and non-immunologic factors leading to vascular injury and inflammation.

Purpose of the Study:

  • To highlight the significance of Cardiac Allograft Vasculopathy (CAV) in heart transplant recipients.
  • To discuss the contributing factors and early features of CAV.
  • To emphasize the importance of early detection and prevention strategies for CAV.

Main Methods:

  • Review of existing literature on Cardiac Allograft Vasculopathy (CAV).
  • Discussion of diagnostic tools including coronary angiography and intravascular ultrasound.

Related Experiment Videos

  • Analysis of contributing factors such as dyslipidemia, oxidant stress, immunosuppressants, and viral infections.

    • Main Results:

    • Endothelial dysfunction is an early indicator of CAV.
    • Intravascular ultrasound reveals negative vascular remodeling contributes to luminal narrowing in CAV.
    • CAV is characterized by accelerated, diffuse obliterative coronary arteriosclerosis.

    Conclusions:

    • Early identification of CAV is crucial for improving long-term prognosis after heart transplantation.
    • Prevention of CAV progression is a primary therapeutic objective.
    • Current revascularization procedures have limited efficacy due to the diffuse nature of CAV.