Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Life-threatening severe malarial anaemia.

M English1

  • 1Department of Paediatrics, University of Oxford, UK. menglish@kilifi.mimcom.net

Transactions of the Royal Society of Tropical Medicine and Hygiene
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A 13-year patient journey of infant giant clival chordoma: case report and literature review.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2022
Same author

Burden of cytomegalovirus disease in allogeneic hematopoietic cell transplant recipients: a national, matched cohort study in an inpatient setting.

Current research in translational medicine·2018
Same author

Variability in distribution and use of tuberculosis diagnostic tests in Kenya: a cross-sectional survey.

BMC infectious diseases·2018
Same author

The other side of the coin.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2016
Same author

Reply to Comment on: The UK Experience of a Treatment Strategy for Pediatric Metastatic Medulloblastoma Comprising Intensive Induction Chemotherapy, Hyperfractionated Accelerated Radiotherapy, and Response-Directed High-Dose Myeloablative Chemotherapy or Maintenance Chemotherapy (Milan Strategy).

Pediatric blood & cancer·2016
Same author

Postoperative visual loss after plastic surgery: case report and a novel continuous real-time video monitoring system for the eyes during prone surgery.

British journal of anaesthesia·2010

Clinical practice changes, especially blood transfusion protocols, may improve survival in children with severe malarial anemia. Further research into the syndrome

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Hematology

Background:

  • Severe malaria remains a significant cause of child mortality globally.
  • Despite advances in understanding, clinical management strategies for severe malaria have seen limited updates.
  • Severe malarial anemia, particularly with metabolic acidosis, presents a high fatality rate in children.

Purpose of the Study:

  • To review current clinical practices for managing severe malarial anemia in children.
  • To argue for the necessity of further research into the clinical physiology of severe malarial anemia.
  • To identify potential improvements in clinical practice, focusing on blood transfusion, to enhance child survival.

Main Methods:

  • This is a review of existing literature and clinical practice.

Related Experiment Videos

  • Focuses on the syndrome of severe, symptomatic malarial anemia with metabolic acidosis.
  • Distinguishes between life-threatening and less severe cases of malarial anemia.

    • Main Results:

    • Preliminary evidence suggests practice changes, not novel interventions, may improve survival in severe malarial anemia.
    • Significant morbidity exists in less severely ill children with severe anemia, also potentially requiring transfusion.
    • Current transfusion practices and rationale for less severely ill children are not addressed and require further research.

    Conclusions:

    • Further research into the clinical physiology of severe malarial anemia is crucial.
    • Compelling evidence may emerge to support changes in clinical practice, particularly regarding blood transfusion.
    • A uniform approach to blood transfusion is not warranted; specific research is needed for less critically ill children.