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Related Experiment Videos

Increased circulating leptin levels in chronic alcoholism.

J M Nicolás1, J Fernández-Solà, F Fatjó

  • 1Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Spain. nicolas@clinic.ub.es

Alcoholism, Clinical and Experimental Research
|February 24, 2001
PubMed
Summary

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Chronic alcoholism is linked to elevated leptin levels, a hormone regulating appetite. This increase is dose-dependent on ethanol consumption and occurs regardless of nutritional status or liver disease in active alcoholics.

Area of Science:

  • Endocrinology
  • Nutritional Science
  • Hepatology

Background:

  • Malnutrition in chronic alcoholics is partly due to reduced energy intake.
  • Leptin, a peptide hormone, regulates appetite and energy expenditure.
  • The role of leptin in alcoholics concerning nutritional status, liver disease, and ethanol intake is unclear.

Purpose of the Study:

  • To investigate serum leptin levels in active alcoholics, abstinent alcoholics, and controls.
  • To determine the relationship between leptin levels, nutritional status, liver disease, and ethanol consumption in alcoholics.

Main Methods:

  • Serum leptin levels were measured in 60 active asymptomatic alcoholics, 20 with cirrhosis, 20 abstinent alcoholics, and 60 controls.
  • Nutritional status and ethanol consumption were assessed in all participants.

Related Experiment Videos

  • Multivariate regression analysis was used to identify factors influencing leptin levels.

    • Main Results:

    • Active alcoholics exhibited significantly higher leptin levels than controls, irrespective of cirrhosis.
    • Abstinent alcoholics did not show elevated leptin levels.
    • Leptin levels in active alcoholics were independently influenced by body fat, lifetime ethanol consumption, and smoking.

    Conclusions:

    • Circulating leptin levels increase in a dose-dependent manner with chronic alcoholism.
    • Elevated leptin is observed regardless of nutritional status or compensated liver disease in active alcoholics.
    • Ethanol consumption is a significant factor in elevated leptin levels among alcoholics.