Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydroxyurea induced leg ulcers.

D Abhyankar1, C Shende, T Saikia

  • 1Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai-400012.

The Journal of the Association of Physicians of India
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consensus Guidelines for the Use of Cyclin-Dependent Kinase (CDK) 4/6 Inhibitors in the Management of Hormone Receptor Positive (HR+ve), Her2-ve Early Breast Cancer (EBC).

South Asian journal of cancer·2025
Same author

Pegfilgrastim: More Cost Effective and Equally Efficacious Option as Compared to Filgrastim in Autologous Stem Cell Transplant.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion·2019
Same author

Engraftment Syndrome: Clinical Features and Predictive Factors in Autologous Stem Cell Transplant.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion·2018
Same author

Musculoskeletal chronic graft versus host disease - A rare complication of allogeneic hematopoietic stem cell transplantation: A case report and review of its literature.

South Asian journal of cancer·2018
Same author

B-cell Chronic Lymphocytic Leukemia in Chronic Immune Thrombocytopenic Purpura: a Case Report.

Leukemia & lymphoma·2016
Same author

The Pattern of Malignant Lymphoma in India: A Study of 1371 Cases.

Leukemia & lymphoma·2016
Same journal

Indian Expert Consensus on Allergic Rhinitis in Women: A Modified Delphi Survey.

The Journal of the Association of Physicians of India·2026
Same journal

Systematic Review of Topical Capsaicin 0.075% for the Treatment of Neuropathic Pain: Efficacy, Safety, and Tolerability.

The Journal of the Association of Physicians of India·2026
Same journal

Sodium-Glucose Cotransporter 2 Inhibitors in Kidney Diseases Other Than That Due to Diabetes: Benefits in Composite Renal Outcomes Driven by Immunoglobulin A Nephropathy.

The Journal of the Association of Physicians of India·2026
Same journal

<i>Fasciolopsis buski</i> Diagnosed by Upper Gastrointestinal Endoscopy.

The Journal of the Association of Physicians of India·2026
Same journal

"Academic Overdose" among Healthcare Professionals.

The Journal of the Association of Physicians of India·2026
Same journal

Respiratory Examination for Postgraduate Residents: Unrevealing Expert's Questions and Answers.

The Journal of the Association of Physicians of India·2026
See all related articles

Hydroxyurea, a treatment for chronic myeloid leukemia (CML), can cause rare leg ulcers. This case highlights the importance of monitoring for and managing this adverse effect.

Area of Science:

  • Oncology
  • Hematology
  • Dermatology

Background:

  • Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm.
  • Hydroxyurea and interferon are common treatments for CML.
  • Adverse drug reactions require careful patient monitoring.

Observation:

  • A 34-year-old non-diabetic female patient with CML developed leg ulcers.
  • Ulcers appeared first on the left toe, then on the right foot.
  • This is a rare complication associated with hydroxyurea therapy.

Findings:

  • Both leg ulcers were managed with local wound care and antibiotics.
  • The hydroxyurea dosage was reduced after the first ulcer occurrence.
  • The drug was discontinued following the development of the second ulcer.

Related Experiment Videos

Implications:

  • Hydroxyurea can lead to rare but significant dermatological complications.
  • Physicians should be vigilant for leg ulcers in CML patients on hydroxyurea.
  • Prompt management and dose adjustment/discontinuation are crucial for treatment success.