Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evaluating mutant mice: anatomic pathology.

C Brayton1, M Justice, C A Montgomery

  • 1Baylor College of Medicine, Houston TX 77030, USA. cbrayton@bcm.tmc.edu

Veterinary Pathology
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Subcutaneous Implants of a Cholesterol-Triglyceride-Buprenorphine Suspension in Rats.

Journal of veterinary medicine·2017
Same author

Immunological variation between inbred laboratory mouse strains: points to consider in phenotyping genetically immunomodified mice.

Veterinary pathology·2011
Same author

Editorial: best pathology practices in research using genetically engineered mice.

Veterinary pathology·2008
Same author

The discovery of moriniafungin, a novel sordarin derivative produced by Morinia pestalozzioides.

Bioorganic & medicinal chemistry·2005
Same author

Near-threshold production of the multistrange Xi- hyperon.

Physical review letters·2003
Same author

Comparison of source images for protons, pi-'s, and lambda's in 6A GeV Au+Au collisions.

Physical review letters·2003
Same journal

An outbreak of H5N1 clade 2.3.4.4b highly pathogenic avian influenza in California condors (<i>Gymnogyps californianus)</i>.

Veterinary pathology·2026
Same journal

Histomorphologic evidence supports a hyperplastic pathogenesis of fibromatous epulis of periodontal ligament origin/peripheral odontogenic fibroma and proposal of fibromatous hyperplasia of the gingival ligament as unifying nomenclature.

Veterinary pathology·2026
Same journal

Image challenge in <i>veterinary pathology</i>.

Veterinary pathology·2026
Same journal

Image challenge in veterinary pathology, answers: Bovine diseases.

Veterinary pathology·2026
Same journal

Immunohistochemical detection of the transcription factor osterix in canine and feline osteosarcoma.

Veterinary pathology·2026
Same journal

Spontaneous rhabdomyosarcomas in <i>Dmd</i><sup><i>mdx</i></sup> rats.

Veterinary pathology·2026
See all related articles

Functional genomics research is advancing, with genetically modified mice becoming crucial models for understanding human diseases. Comparative pathology and phenotypic characterization of these mouse models are essential for identifying gene functions in whole organisms.

Area of Science:

  • Genomics
  • Molecular Biology
  • Pathology

Background:

  • Genome projects are nearing completion, increasing the need for functional genomics.
  • Genetically modified mice are vital models for studying human diseases.
  • The use of mice in biomedical research has significantly increased since the 1980s.

Purpose of the Study:

  • To highlight the growing importance of functional genomics.
  • To emphasize the role of mutant mouse models in understanding human genetic conditions.
  • To underscore the increasing significance of comparative pathology in this field.

Main Methods:

  • Utilizing genetically modified mouse models.
  • Employing clinical pathology techniques for evaluation.
  • Applying anatomic pathology for phenotypic characterization.

Related Experiment Videos

Main Results:

  • Genetically modified mice are increasingly used in biomedical research.
  • Comparative pathology is becoming more critical in disease research.
  • Phenotypic characterization of mutant mice is key to functional genomics.

Conclusions:

  • Functional genomics requires understanding gene function in the context of the whole organism.
  • Mutant mouse models are indispensable for genetic disease research.
  • Clinical and anatomic pathology are crucial for evaluating mutant mice in functional genomics initiatives.