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[Chronic recurrent multifocal osteomyelitis].

F Schilling¹, A Eckardt, S Kessler

¹Rheinland-Pfälzisches Rheuma-Zentrum Mainz-Bad Kreuznach.

Zeitschrift Fur Orthopadie Und Ihre Grenzgebiete

|February 24, 2001

Summary

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Chronic recurrent multifocal osteomyelitis (CRMO) is a systemic aseptic bone inflammation. This study details its clinical, radiological, and histopathological features, emphasizing it

Area of Science:

Rheumatology
Pediatrics
Dermatology

Context:

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, aseptic bone inflammation.
The condition presents with diverse clinical, radiological, and histopathological findings.
Distinguishing CRMO from other bone pathologies is crucial for appropriate management.

Purpose:

To provide a comprehensive description of CRMO based on clinical, radiological, and histopathological data from 29 cases.
To correlate findings with existing literature and delineate key characteristics of the disease.
To discuss current treatment modalities and diagnostic approaches for CRMO.

Summary:

CRMO is a systemic aseptic osteitis, potentially polytopic, and may associate with dermatologic symptoms.

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The disease exhibits a characteristic three-phase histologic course and specific localization patterns identifiable via imaging.

Arthritis, particularly sympathetic coxitis, frequently co-occurs; drug therapies like azithromycin and bisphosphonates are discussed.

Impact:

Highlights the importance of 99mTC bone scans for CRMO diagnosis and pattern identification.
Recommends consultation with rheumatologists and dermatologists for comprehensive patient care.
Advocates against the term SAPHO syndrome, stressing the need for precise CRMO diagnosis and conservative management, as the condition is often self-limiting.