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[Scanning electron microscopy findings in titanium middle ear prostheses].

K Schwager1

  • 1Klinik und Poliklinik für Hals-, Nasen- und Ohrenkranke der Universität Würzburg. k.schwager@mail.uni-wuerzburg.de

Laryngo- Rhino- Otologie
|February 24, 2001
PubMed
Summary

Titanium prostheses show excellent biocompatibility for ossicular replacement surgery. Even in cases of chronic inflammation, titanium implants were well-accepted, with no signs of rejection observed.

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Area of Science:

  • Biomaterials science
  • Otolaryngology
  • Tissue engineering

Context:

  • Titanium has become a prevalent biomaterial for ossicular replacement prostheses.
  • Understanding the long-term biocompatibility of titanium in the middle ear is crucial.

Purpose:

  • To evaluate the tissue response and biocompatibility of titanium ossicular replacement prostheses (PORPs and TORPs) after explantation.
  • To assess tissue integration, epithelialization, and signs of inflammation or rejection.

Summary:

  • Scanning electron microscopy of 23 explanted titanium prostheses (12 PORPs, 11 TORPs) revealed unremarkable connective tissue and varying degrees of epithelialization.
  • Respiratory epithelium was observed in two cases, and squamous epithelium was noted, particularly in cases of cholesteatoma.

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  • No cellular signs of incompatibility, such as macrophages or foreign body giant cells, were detected, even in the presence of lymphocytic infiltration due to underlying disease.

    • Impact:

    • Titanium demonstrates favorable biocompatibility for ossicular replacement, even in challenging inflammatory environments.
    • These findings support the continued use of titanium as a reliable biomaterial in middle ear reconstructive surgery.