Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Additive analgesia without opioid side effects.

¹National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA.

Compendium of Continuing Education in Dentistry (Jamesburg, N.J. : 1995)

|February 24, 2001

Summary

Combining nonsteroidal anti-inflammatory drugs (NSAIDs) with acetaminophen offers improved postoperative pain relief for dental patients. This combination provides greater analgesia without the increased side effects commonly seen with opioid use.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Genome-wide approaches (GWA) in oral and craniofacial diseases research.

Oral diseases·2012

Same author

COX-2 inhibitors--IBC conference. 12-13 April 1999, Coronado, CA, USA.

IDrugs : the investigational drugs journal·2005

Same author

Nitric oxide in experimental joint inflammation. Benefit or detriment?

Cells, tissues, organs·2003

Same author

Oral midazolam syrup: a safer alternative for pediatric sedation.

Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)·2001

Same author

Preemptive vs preventive analgesia: which approach improves clinical outcomes?

Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)·2001

Same author

COX-2 inhibitors: better than ibuprofen for dental pain?

Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)·2000

Area of Science:

Pain Management
Pharmacology
Dental Anesthesiology

Background:

Inadequate postoperative pain control is a significant clinical challenge.
Current analgesics like NSAIDs and opioids have limitations in efficacy and side effect profiles.
Opioid combinations with acetaminophen or aspirin do not enhance analgesia but increase adverse events.

Purpose of the Study:

To evaluate the efficacy of combining NSAIDs with acetaminophen for postoperative dental pain.
To assess if this combination offers superior analgesia compared to monotherapy.
To determine if this combination avoids the side effects associated with opioid use.

Main Methods:

The study focuses on the pharmacological principles of combining NSAIDs and acetaminophen.
It reviews existing literature on analgesic efficacy and side effect profiles.
The context is ambulatory dental patients experiencing postoperative pain.

Main Results:

NSAIDs are effective for dental pain but have a ceiling effect.
Combining NSAIDs with acetaminophen shows promise for enhanced analgesia.
This combination avoids the increased drowsiness and nausea linked to opioids.

Conclusions:

The combination of NSAIDs and acetaminophen presents a promising strategy for improved postoperative dental pain management.
This approach may offer superior pain relief without the adverse effects of opioid-based regimens.
Further clinical studies are warranted to confirm these findings in ambulatory dental patients.

Related Experiment Videos