Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ischemic carotid endothelium. Scanning electron microscopical studies.

E Nelson, T Sunaga, T Shimamoto

    Archives of Pathology
    |March 1, 1975
    PubMed
    Summary

    Ischemia causes distinct crater-like defects in the endothelium of common carotid arteries in rhesus monkeys. These changes appear rapidly, highlighting the vulnerability of the blood vessel lining to reduced blood flow.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Assessing trace-elements as indicators of marine finfish aquaculture across three distinct Canadian coastal regions.

    Marine pollution bulletin·2021
    Same author

    Genome sequence and description of <i>Blautia brookingsii</i> SG772 sp. nov., a novel bacterial species isolated from human faeces.

    New microbes and new infections·2020
    Same author

    Voluntary sustainability standards could significantly reduce detrimental impacts of global agriculture.

    Proceedings of the National Academy of Sciences of the United States of America·2019
    Same author

    Serological evidence for the co-circulation of two lineages of influenza D viruses in equine populations of the Midwest United States.

    Zoonoses and public health·2017
    Same author

    Quality specifications in postgraduate medical e-learning: an integrative literature review leading to a postgraduate medical e-learning model.

    BMC medical education·2016
    Same author

    Use of Pipeline Embolization Devices for treatment of a direct carotid-cavernous fistula.

    Acta neurochirurgica·2015

    Area of Science:

    • Vascular biology
    • Pathology
    • Microscopy

    Background:

    • The endothelium maintains vascular homeostasis.
    • Ischemia can lead to endothelial dysfunction and damage.
    • Understanding early ischemic effects is crucial for neuroprotection.

    Purpose of the Study:

    • To investigate the ultrastructural changes in the common carotid artery endothelium following ischemia.
    • To characterize the morphological effects of varying durations of ischemia on endothelial cells.

    Main Methods:

    • Scanning electron microscopy (SEM) was used to examine rhesus monkey common carotid arteries.
    • Controlled ischemia was induced by vessel occlusion for 5 minutes to 4 hours.
    • Sham-operated and unoperated animals served as controls.

    Related Experiment Videos

    Main Results:

    • Ischemia induced characteristic conical, crater-like defects in endothelial cell cytoplasm.
    • These defects were observed after just 15 minutes of ischemia.
    • Defects were significantly less frequent in sham-operated controls and absent in unoperated controls.

    Conclusions:

    • Early ischemia causes distinct, observable damage to the carotid artery endothelium.
    • SEM is effective in visualizing these acute ischemic endothelial alterations.
    • These findings provide insights into the initial cellular responses to vascular occlusion.