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[Stress-limiting nitric oxide system].

E B Manukhina¹, I Iu Malyshev

¹Institute of General Pathology and Pathophysiology of the Russian Acad. Med. Sci., Baltiyskaya St., 8, Moscow 125315, Russia.

Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova

|February 24, 2001

Summary

The nitric oxide (NO) system acts as a universal controller of bodily functions and a novel stress-limiting mechanism. It mitigates stress hormone release and damage, boosting resistance and aiding adaptation to environmental factors.

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Area of Science:

Physiology
Biochemistry
Stress Response

Context:

The body's response to stress involves complex physiological and hormonal mechanisms.
Understanding novel regulatory systems is crucial for managing stress and adaptation.

Purpose:

To establish the nitric oxide (NO) system as a universal physiological transmitter and controller.
To define the NO system as a new stress-limiting system.

Summary:

The NO system is activated by stress, limiting stress hormone release and damage.
It enhances organismal resistance and facilitates adaptation to repeated environmental exposures.
Specific characteristics differentiate the NO system from other known stress-limiting systems.

Impact:

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Provides a new framework for understanding physiological regulation and stress response.
Highlights the potential of the NO system as a therapeutic target for stress-related conditions.
Enhances knowledge of biological adaptation mechanisms to environmental challenges.