Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral and central sensitization during migraine.

A Malick1, R Burstein

  • 1Department of Neurobiology, Program in Neuroscience, Harvard Medical School, Boston, MA, USA.

Functional Neurology
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tickborne microorganisms in Dermacentor andersoni (Acari: Ixodidae) in the Bitterroot Mountains of Western Montana.

Ticks and tick-borne diseases·2025
Same author

Biological and behavioral markers of pain following nerve injury in humans.

Neurobiology of pain (Cambridge, Mass.)·2020
Same author

A 'complex' of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients.

NeuroImage. Clinical·2016
Same author

Sex and the migraine brain.

Neurobiology of disease·2014
Same author

The impact of hot melt extrusion and spray drying on mechanical properties and tableting indices of materials used in pharmaceutical development.

Journal of pharmaceutical sciences·2013
Same author

Hypothalamic and basal ganglia projections to the posterior thalamus: possible role in modulation of migraine headache and photophobia.

Neuroscience·2013

Migraine pain involves chemical activation of meningeal nerves. This study shows this activation causes peripheral and central sensitization in pain pathways, explaining migraine symptoms like throbbing pain and scalp tenderness.

Area of Science:

  • Neuroscience
  • Pain Research
  • Migraine Pathophysiology

Background:

  • Migraine pain theories focus on meningeal perivascular fiber activation.
  • Understanding the trigeminovascular system's role in migraine is crucial.

Purpose of the Study:

  • To investigate the effects of chemical activation of meningeal primary afferent nociceptors in an animal migraine model.
  • To elucidate the mechanisms underlying migraine pain, including peripheral and central sensitization.

Main Methods:

  • Utilized an animal model to study migraine pathophysiology.
  • Focused on chemical activation of dural innervating primary afferent nociceptors.
  • Assessed sensitization to intracranial and extracranial stimuli and cardiovascular responses.

Related Experiment Videos

Main Results:

  • Chemical activation induced peripheral sensitization of nociceptors to mechanical stimuli.
  • Central sensitization of trigeminovascular neurons occurred, responding to extracranial stimuli.
  • Facilitated cardiovascular pressor responses, indicative of pain, were observed.

Conclusions:

  • First evidence for peripheral and central sensitization induced by dural input along trigeminovascular pathways.
  • Migraine pain is primarily mediated by peripheral sensitization and secondarily by central sensitization.
  • Scalp tenderness in migraine is mainly attributed to central sensitization.